Department of Chemistry
Seoul National University
​39. Hyunuk Eom, Jaeeun Sim, Woon Ju Song* "Quercetin 2,4-dioxygenase" Encyclopedia of Inorganic and Bioinorganic Chemistry, 2024, under revision.
38. Hyunuk Eom, Kye Soo Cho, Jihyeon Lee, Stephanie Kim, Sukhwan Park, Hyunbin Kim, Jinsol Yang, Young-Hyun Han, Juyong Lee, Chaok Seok, Myeong Sup Lee*, Woon Ju Song* Martin Steinegger* “Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model” Nucleic Acids Res., 2024, accepted.
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37. Tobias Vornholt, Florian Leiß-Maier, Woo Jae Jeong, Cathleen Zeymer*, Woon Ju Song*, Gerard Roelfes*, Thomas R. Ward* “Artificial Metalloenzymes” Nat. Rev. Method. Prim., 2024, 4, 78. Read-only link​
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36. Soyeun Son, Woon Ju Song* "Programming Interchangeable and Reversible Heterooligomeric Protein Self-assembly Using a Bifunctional Ligand" Chem. Sci., 2024, 15, 2975–2983.
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35. Woo Jae Jeong,† Jaehee Lee,† Hyunuk Eom,† Woon Ju Song* “A Specific Guide for Metalloenzyme Designers: Introduction and Evolution of Metal-Coordination Spheres Embedded in Protein Environments” Acc. Chem. Res., 2023, 56, 2416–2425 †Authors contributed equally to this work.
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34. Hyunuk Eom, Yuanxin Cao, Hyunsoo Kim, Sam P. de Visser* Woon Ju Song* “Underlying Role of Hydrophobic Environments in Tuning Metal Elements for Efficient Enzyme Catalysis” J. Am. Chem. Soc., 2023, 145, 5880-5887.
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33. Jaehee Lee, Woon Ju Song,* “Photocatalytic C–O Coupling Enzymes that Operate via Intramolecular Electron Transfer”
J. Am. Chem. Soc., 2023, 145, 5211-5221. Also selected in the Spotlights on Recent JACS Publications.
32. Hwanjin Joo, Hyunuk Eom, Youna Cho, Mina Rho,* Woon Ju Song* “Discovery and Characterization of Polymyxin-resistance Genes pmrE and pmrF from Sediment Microbiome” Microbiol. Spectr., 2023, e02736-22.
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31. Jaehee Lee,† Minwoo Yang,† Woon Ju Song,* "The Expanded Landscape of Metalloproteins by Genetic Incorporation of Noncanonical Amino Acids" Bull. Korean Chem. Soc., 2023, 44, 23-34. †Authors contributed equally to this work.
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30. Woo Jae Jeong, Woon Ju Song,* “Design and Directed Evolution of Noncanonical β-Stereoselective Metalloglycosidases” Nat. Commun., 2022, 13, 6844
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29. Minwoo Yang, Woon Ju Song,* “One-pot Two-step Synthesis of Micro- and Mesoporous Organic Fibrils for Efficient Pseudocapacitors” J. Mater. Chem. A, 2022, 10, 17511–17519
28. Se-Min Jung, Minwoo Yang, Woon Ju Song* “Symmetry-adapted Synthesis of Dicopper Oxidases with Divergent Dioxygen Reactivity" Inorg. Chem., 2022, 61, 12433–12441
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27. Inseok Song, Younghyeon Kim, Jaeseung Yu, Su Yong Go, Hong Geun Lee, Woon Ju Song, Seokhee Kim* "Molecular Mechanism Underlying Substrate Recognition of the Peptide Macrocyclase PsnB" Nat. Chem. Biol., 2021, 17, 1123-1131
26. Se-Min Jung,† Jaehee Lee,† Woon Ju Song,* "Design of Artificial Metalloenzymes with Multiple Inorganic Elements: The More the Merrier", J. Inorg. Biochem., 2021, 223, 111552. †Authors contributed equally to this work.
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25. Jaewon Lee, Woon Ju Song,* "Folding of Circularly Permutated and Split Outer Membrane Protein F via Electrostatic Interactions with Terminal Residues", Biochemistry, 2021, 60, 1787-1796
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24. Jehyun Jeon,† Jaehee Lee,† Se-Min Jung, Jae Hong Shin, Woon Ju Song,* and Mina Rho* “Genomic Determinants Encode for the Reactivity and Regioselectivity of Flavin-Dependent Halogenases in Bacterial Genomes and Metagenomes”, mSystems, 2021, 6, e00053-21 †Authors contributed equally to this work.
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23. Jaeseung Yu, Jinsol Yang, Chaok Seok, Woon Ju Song* “Symmetry-related Residues as Promising Hotspots for the Evolution of De Novo Oligomeric Enzymes”, Chem. Sci., 2021, 12, 5091-5101 (Selected as the back cover and as a part of 2021 Chemical Science HOT Article Collection)
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22. Woo Jae Jeong,† Jaeseung Yu,† Woon Ju Song* "Proteins as Diverse, Efficient, and Evolvable Scaffolds for Artificial Metalloenzymes" Chem. Commun., 2020. 56, 9586-9599 †These authors contributed equally to this work.
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21. Mina Rho,* Woon Ju Song* “Discovery of Novel Gene Functions by Chemistry-Guided Targeted Sequence Analysis” Biochemistry, 2020, 59, 10-11 (Invited in the "Future of Biochemistry" issue)
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20. Minwoo Yang, Woon Ju Song* "Diverse Protein Assembly Driven by Metal and Chelating Amino Acids with Selectivity and Tunability" Nat. Commun., 2019, 10, 5545
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19. Hyunuk Eom, Woon Ju Song* "Emergence of Metal Selectivity and Promiscuity in Metalloenzymes" J. Biol. Inorg. Chem., 2019, 24, 517-531
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18. Jae Hong Shin,† Hyunuk Eom,† Woon Ju Song* Mina Rho* "Integrative Metagenomic and Biochemical Studies on Rifamycin ADP-ribosyltransferases Discovered in the Sediment Microbiome" Sci. Rep., 2018, 8, 12143 †These authors contributed equally to this work.
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17. Woon Ju Song,* Jaeseung Yu, F. Akif Tezcan* "Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-β-lactamases" J. Am. Chem. Soc., 2017, 139, 16772
Pre-SNU
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16. Woon Ju Song, F. Akif Tezcan “A Designed Supramolecular Protein Assembly with In Vivo Enzymatic Activity” Science, 2014, 346, 1525-1528. This work was highlighted in Nat. Chem., 2015, 7, 277-279.
15. Pamela A. Sontz,† Woon Ju Song,† F. Akif Tezcan “Engineered Metal Coordination in Protein and Peptide Interfaces” Curr. Opin. Chem. Biol., 2014, 19, 42-49 †These authors contributed equally to this work.
14. Woon Ju Song,† Pamela A. Sontz,† Xavier Ambroggio, F. Akif Tezcan “Metals in Protein-Protein Interfaces” Annu. Rev. Biophys., 2014, 43, 409-431 †These authors contributed equally to this work.
13. Woon Ju Song, Grant Gucinski, Matthew H. Sazinsky, Stephen J. Lippard “Tracking a Defined Route for O2-Migration in a Dioxygen-Activating Diiron Enzyme” Proc. Natl. Acad. Sci., 2011, 108, 14795-14800
12. Woon Ju Song, Stephen J. Lippard “Mechanistic Studies of Reactions of Peroxodi-iron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase” Biochemistry, 2011, 50, 5391–5399
11. Arteum D. Bochevarov, Jianing Li, Woon Ju Song, Richard A. Friesner, Stephen J. Lippard “Insights into the Different Dioxygen Activation Pathways of Methane and Toluene Monooxygenase Hydroxylases” J. Am. Chem. Soc., 2011, 133, 7384-7397
10. Christine E. Tinberg, Woon Ju Song, Viviana, Izzo, Stephen, J. Lippard “Multiple Roles of Component Proteins in Bacterial Multicomponent Monooxygenases: Phenol Hydroxylase and Toluene/o-Xylene Monooxygenase from Pseudomonas sp. OX1” Biochemistry, 2011, 50, 1788-1798
9. Woon Ju Song, Michael S. McCormick, Rachel K. Behan, Matthew H. Sazinsky, Wei Jiang, Jeffery Lin, Carsten Krebs, Stephen J. Lippard “Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase” J. Am. Chem. Soc., 2010, 132, 13582-13585
8. Woon Ju Song, Rachel K. Behan, Sunil G. Naik, Boi Hanh Huynh, Stephen J. Lippard “Characterization of a Peroxodiiron(III) Intermediate in the T201S Variant of Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas sp. OX1” J. Am. Chem. Soc., 2009, 131, 6074-6075
7. Min-Jung Kang, Woon Ju Song, Ah-Rim Han, Young S. Choi, Ho G. Jang, Wonwoo Nam “Mechanistic Insight into the Aromatic Hydroxylation by High-Valent Iron(IV)-oxo Porphyrin π-Cation Radical Complexes” J. Org. Chem., 2007, 72, 6301-6304
6. Woon Ju Song, Mi Sook Seo, Serena DeBeer George, Takehiro Ohta, Rita Song, Min-Jung Kang, Takehiko Tosha, Teizo Kitagawa, Edward I. Solomon, Wonwoo Nam “Synthesis, Characterization, and Reactivities of Manganese(V)-Oxo Porphyrin Complexes” J. Am. Chem. Soc., 2007, 129, 1268-1277
5. Woon Ju Song, Ying Ji Sun, Sun Kyung Choi, Wonwoo Nam “Mechanistic Insights into the Reversible Formation of Iodosylarene–Iron Porphyrin Complexes in the Reactions of Oxoiron(IV) Porphyrin π-Cation Radicals and Iodoarenes: Equilibrium, Epoxidizing Intermediate, and Oxygen Exchange” Chem. Eur. J., 2005, 12, 130-137
4. Woon Ju Song, Yon Ok Ryu, Rita Song, Wonwoo Nam “Oxoiron(IV) Porphyrin π-Cation Radical Complexes with a Chameleon Behavior in Cytochrome P450 Model Reactions” J. Biol. Inorg. Chem., 2005, 10, 294-304
3. Se-Eun Park, Woon Ju Song, Yon Ok Ryu, Mi Hee Lim, Rita Song, Kwan Mook Kim, Wonwoo Nam “Parallel Mechanistic Studies on the Counterion Effect of Manganese Salen and Porphyrin Complexes on Olefin Epoxidation by Iodosylarenes” J. Inorg. Biochem., 2005, 99, 424-431
2. Wonwoo Nam, Yon Ok Ryu, Woon Ju Song “Oxidizing Intermediates in Cytochrome P450 Model Reactions” J. Biol. Inorg. Chem., 2004, 9, 654-660
1. József Kaizer, Eric J. Klinker, Na Young Oh, Jan-Uwe Rohde, Woon Ju Song, Audria Stubna, Jinheung Kim, Eckard Münck, Wonwoo Nam, Lawrence Que, Jr. “Nonheme FeIVO Complexes That Can Oxidize the C-H Bonds of Cyclohexane at Room Temperature” J. Am. Chem. Soc., 2004, 126, 472-473
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